This article reviews the uses, benefits, and safety of titanium dioxide.

Australian researchers examined how titanium dioxide as a food additive affected gut microbiota in mice by orally administering it in drinking water. The study, published in the journal Frontiers in Nutrition in 2019, found the treatment could “alter the release of bacterial metabolites in vivo and affect the spatial distribution of commensal bacteria in vitro by promoting biofilm formation. We also found reduced expression of the colonic mucin 2 gene, a key component of the intestinal mucus layer, and increased expression of the beta defensin gene, indicating that titanium dioxide significantly impacts gut homeostasis.” The changes were then linked to colonic inflammation, along with a higher expression of inflammatory cytokines, which are signal proteins that help with regulation. The researchers concluded that titanium dioxide “impairs gut homeostasis which may in turn prime the host for disease development.”

According to Procurement Resource, the price of Titanium dioxide is estimated to depict a declining trends in the upcoming quarter. The price trends will be mostly affected by the weakened demand from the paint and coatings industries and the rise in global inflation.

The report provides insights into the landscape of the lithopone industry at the global level. The report also provides a segment-wise and region-wise breakup of the global lithopone industry. Additionally, it also provides the price analysis of feedstocks used in the manufacturing of lithopone, along with the industry profit margins.

Titanium dioxide is typically micronized and coated for use in cosmetics products. The micronizing makes this somewhat heavy-feeling ingredient easier to spread on skin, plus a bit more cosmetically elegant. Micronized titanium dioxide is much more stable and can provide better sun protection than non-micronized titanium dioxide.

Throughout the fourth quarter of 2021, the European market had consistent optimistic sentiment. Despite the overwhelming inventories at lower levels during the fourth quarter of 2021, the demand prognosis in the domestic market revealed varied opinions. Imports from the Asia Pacific region, on the other hand, remained disruptive due to limited accessibility of vessel freights and a decrease in the PMI index for titanium dioxide in China despite the application of severe environmental protection measures.

When choosing lithopone, you must choose a good brand and pay attention to its production date. Some people just don’t pay attention to this aspect and often pursue cheap prices. As a result, they buy products that are close to their expiration date and have not been stored for long. It is no longer usable. This is very important.

2.Inorganic white pigment. Widely used as a white pigment for plastics, paints and inks such as polyolefins, vinyl resins, ABS resins, polystyrene, polycarbonate, nylon and polyoxymethylene.

Lithopone is an inorganic white pigment, obtained from co-precipitation of Zinc sulfide (ZnS) and Barium sulfate (BaSO4). Titanium Dioxide (TiO2) has replaced Lithopone as a white pigment in majority applications as TiO2 is more durable. However, it is much cheaper than TiO2 and has advantages such as low binder requirement and good dispensability. As a white pigment, it can improve the substrate's weather resistance, and improve the fungicidal properties of paint formulations. Some of the major applications of Lithopone include manufacturing of paint pigments, plastic & rubber products, paper, printing inks, cosmetics, and leather & linoleum products. It is commercially available under names such as pigment white 5, Barium zinc sulfate sulfide, Becton White, C.I. 77115, Charlton White, Enamel White, and Zincolith. On the basis of content of ZnS, Lithopone is available at 28%-30% Lithopone and 60% Lithopone.

A 2023 study published in the journal Particle and Fibre Toxicology set out to examine the impact of titanium dioxide nanoparticles in mice “on the course and prognosis of ulcerative colitis,” by creating an ulcerative colitis disease model. Researchers found that the titanium dioxide nanoparticles significantly increased the severity of colitis. They also “decreased the body weight, increased the disease activity index and colonic mucosa damage index scores, shortened the colonic length, increased the inflammatory infiltration in the colon.” Researchers concluded: “Oral intake of TiO2 nanoparticles could affect the course of acute colitis in exacerbating the development of ulcerative colitis, prolonging the ulcerative colitis course and inhibiting ulcerative colitis recovery.”

Nano-sized TiO₂ generally shows low or no acute toxicity in both invertebrates and vertebrates. However, exposure of Daphnia magna to 20 ppm TiO₂ for 8 consecutive days was found to cause 40 % mortality. Zhu et al. showed minimal toxicity to D. magna after 48 h exposure, while upon chronic exposure for 21 days, D. magna suffered severe growth retardation and mortality. A significant amount of nano-sized TiO₂ was found also accumulated in the body of the animals. Similar findings with coated nano-sized TiO₂ (T-Lite™ SF, T-Lite™ SF-S and T-Lite™ MAX; BASF SE) were reported by Wiench et al. Biochemical measurements showed that exposure to TiO₂ NPs induces significant concentration-dependent antioxidant enzyme activities in D. magna. Lee et al. showed that 7 and 20 nm-sized TiO₂ induced no genotoxic effect in D. magna and in the larva of the aquatic midge Chironomus riparius.

The North American region suffered from the excess influx of material in the market, especially from the Asian countries, in the first half of the third quarter. The quarter, however, showed signs of significant improvement with a rise in the number of offtakes. Further, the lack of labor in the US challenged the rates of production of titanium dioxide and resulted in the depletion in the level of existing inventories, pushing the titanium dioxide price graph in an upward direction.

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